Yunus Emre

The increasing global population and climate change threaten food security, with the need for sustenance expected to rise by 85% by 2050. Rice, a crucial staple food for over 50% of the global population, is a major source of calories in underdeveloped and developing countries. However, by the end of the century, over 30% of rice fields will become saline due to soil salinity caused by earthquakes, tsunamis, and rising sea levels. Plants have developed strategies to deal with salt stress, such as ion homeostasis, antioxidant defense mechanisms, and morphological adaptations. Proline, an endogenous osmolyte, is the predominant endogenous osmolyte that accumulates in response to salinity, and its overexpression in rice plants has been observed to increase plant salinity tolerance. Exogenously applied proline has been shown to improve plant salt tolerance by reducing the destructive effect of salinity. Recent research has focused on ionic toxicity, nitrogen fixation, and gene expression related to salt tolerance. Exogenous proline has been shown to improve water potential and leaf content, restoring water usage efficiency. It can also ease growth inhibition in salt-sensitive plants. Exogenously applied proline increases antioxidant activities and enhances plant salinity tolerance. This review examines the role and processes of proline in rice plants under salt stress and its relationship with other tolerance mechanisms.

School of Physical Education and Sports, Siirt University, Siirt 56100, Turkey School of Physical Education and Sports, Batman University, Batman 72000, Turkey

Department of Medical Oncology, Health Science University, Kartal Dr. Lütfi Kirdar City Hospital, Istanbul 34865, Turkey

Scientific Reports , Article number: Cite this article Abstract

Background: The treatment and escape for metastatic renal cell carcinoma (RCC) has rapidly evolved, particularly with the integration of immune therapies into first-line regimens. However, optimal strategies following progression in first-line immunotherapy remain uncertain. This study aims to evaluate the efficacy and safety of axitinib and cabozantinib as third-line therapies after progression on nivolumab following first-line VEGF-TKI therapy. Methods: Patients with metastatic RCC who progressed on prior nivolumab treatment after receiving first-line VEGF-TKI therapy were included. Data on patient characteristics, treatment regimens, response rates, progression-free survival (PFS), and overall survival (OS) were collected. Statistical analyses were conducted to assess the prognostic factors and treatment outcomes. Results: A total of 46 patients were included who were predominantly male (83%) with clear-cell histology (89%). The median PFS on first-line TKI therapy was 10.2 months. All the patients received nivolumab as a second-line therapy, with a median of 12 cycles. The median second-line PFS was seven months. Third-line therapies included axitinib (24 patients) and cabozantinib (20 patients). The median PFS for axitinib and cabozantinib was six months, with comparable survival outcomes. The IMDC risk group and treatment tolerability were significant predictors of survival in multivariate analysis. Adverse events were manageable, with hypertension, fatigue, and diarrhea being the most common. Conclusion: Axitinib and cabozantinib show promise as third-line therapies post-nivolumab progression in metastatic RCC, though prospective validation is warranted. This study underscores the need for further research to establish treatment standards in this evolving landscape.

Abstract Triple negative breast cancer (TNBC) subtype is characterized with higher EMT/stemness properties and immune suppressive tumor

Abstract Open surgery for developmental dysplasia of the hip (DDH) may cause severe pain due to tenotomies and pelvic–femoral osteotomies.

Abstract Background Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is a recurrent fever syndrome.

Today, various systems are used to reduce vibrations in civil engineering structures. Among these systems, tuned liquid dampers are the preferred passive systems due to their ability to be designed in different geometries, their low cost, their ease of installation, and their low maintenance costs. This study examines the effectiveness of tuned liquid dampers (TLD) and tuned liquid column dampers (TLCD) under identical geometric conditions and harmonic ground motion to assess which is more efficient in controlling the behavior of a three-storey steel shear frame model equipped with these systems. A small-scale, three-storey shear frame model placed on a uniaxial shaking table was subjected to harmonic motion with a 5 mm amplitude, 1.4 Hz frequency, and 10 cycles. The chosen frequency aligns with the resonance frequency of the undamped building model's first mode. Both TLD and TLCD tanks, positioned atop the structure, share a geometry of 30 cm in length and 10 cm in width, with variable liquid heights of 5, 10, 15, and 20 cm. Mounting TLD and TLCD models with four different liquid heights on the undamped model resulted in nine distinct setups. In this designed scenario, the TLDs and TLCDs on the undamped shear frame were compared according to liquid heights at rest. To identify the best-performing system based on liquid height, response displacement–frequency graphs were generated for all models within a frequency range of 0.5–2.5 Hz, and damping ratios were calculated using the half-power bandwidth method. Additionally, harmonic ground motion experiments at the resonance frequency compared both acceleration and displacement values over time for damped and undamped models. Peak acceleration and displacement values on each floor were also analyzed. The results highlight which system proves more effective based on damping ratio, acceleration, and displacement values under equivalent conditions.

Department of Medical Oncology, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul 34865, Türkiye