Anna M.

DSBGA, Dipartimento di Scienze Biologiche, Geologiche e Ambientali, University of Catania, Corso Italia 57, 95129 Catania, Italy

Abstract Currently available clinical treatments on alcohol use disorder (AUD) exhibit limited efficacy and new druggable targets are required.

Marriage is a key adult milestone yet is also considered a greedy institution that monopolizes resources, jeopardizing adult children's financial transfers to aging parents. As the age at which marriage shifts later into adulthood, this study examines whether marriage still operates as a greedy institution, considering the role of marital timing on upward financial transfers to aging parents. Using data from Waves I–V of Add Health and Wave I of the Add Health Parent Questionnaire from 1994 to 2018, we examined whether timing of marriage (never, early, on time, and late) was associated with adult children's upward financial transfers to their parents, accounting for variation across gender, race, and ethnicity. Adult children who never married were the largest group who gave upward financial transfers to their aging parents (33%). Results suggested that marriage or timing of marriage was a greedy institution among men, women, white, Hispanic, and Asian adults, but not Black adults, suggesting heterogeneity in the role of marriage on family support.

Abstract Cognitive deficits are long-lasting consequences of drug use, yet the convergent mechanism by which classes of drugs with different

In-depth in vivo and in vitro functional analyses, along with a series of genomic assays, reveal RNF20 as a molecular rheostat controlling the balance between endothelial VEGF and Notch signaling during sprouting angiogenesis.

Endocrinology Research Centre, 115478 Moscow, Russia 3D-Shaper Medical, 08007 Barcelona, Spain

Abstract Habitual responses towards addiction-related cues play a relevant role in the development and maintenance of addictions.

An aerobic, obligately chemolithoautotrophic, sulfur-oxidizing bacterium, strain AK1T, was isolated from a terrestrial hot spring of the Uzon Caldera, Kamchatka, Russia. The cells of the new isolate were Gram-negative motile rods with a single polar flagellum. Strain AK1T grew at 37–55 °C (optimum 50 °C) with 0–1.0% NaCl (optimum 0%) and within the pH range 4.8–7.0 (optimum pH 5.2–5.5). The new isolate was able to grow by aerobic respiration with sulfide, sulfur, or thiosulfate as the electron donor and HCO3−/CO2 as the carbon source. The major fatty acids were C16:0, C17:1 Δ, and C16:1 ω7c. The respiratory lipoquinone was ubiquinone UQ-8. The size of the genome and genomic DNA G+C content of the strain AK1T were 2.55 Mb and 64.0%, respectively. The closest 16S rRNA gene sequence of a validly published species belonged to Thiobacter subterraneus C55T (97.94% identity). According to the 16S rRNA gene sequence-based and conserved protein sequences-based phylogenetic analyses, strain AK1T represented a distinct lineage of the genus Thiobacter within a new family, Thiobacteraceae of the order Burkholderiales. As inferred from the morphology, physiology, chemotaxonomy, and phylogeny, strain AK1T ought to be recognized as a novel species for which we propose the name Thiobacter aerophilum sp. nov. The type strain is AK1T (=CGMCC 1.18099T = UQM 41819T).

Nonrigid forms of motion are commonplace in everyday life. Given previously documented age-related deteriorations in various tasks involving motion (discriminating speed, identifying motion direction, etc.), an experiment was conducted to evaluate the potential effect of age upon the visual ability to detect rigid and nonrigid object motion. Thirty younger and older observers participated in the experiment (mean ages were 19.9 and 75.8 years, respectively). As has been done multiple times in the past, the individual motions of object vertices were manipulated to simulate either rigid motion (rotation in depth, with or without precession) or two different types of nonrigid motion (also rotation in depth with or without precession, but with added object deformation). In confirmation of previous research, there were large effects of nonrigid motion type and precession upon the ability to differentiate between rigid and nonrigid object motion. There was also a large effect of age, such that the discrimination performance of the younger observers was 49.6% higher than that exhibited by the older observers. In this first ever study of aging and nonrigid object motion perception, we thus find that aging is associated with a substantial impairment in the ability to visually perceive object nonrigidity.

Recent years have brought new, highly effective systemic treatments to clinical practice, which can be used to treat patients with locally advanced or metastatic skin cancers. Using these regimens in neoadjuvant strategy influences surgical treatment by facilitating surgical resection, avoiding extensive resections with complex reconstructions and even omitting surgery in some cases. Integrating systemic therapy with surgery is ongoing and requires novel quality measures of surgical treatment to capture the clinical benefits of multidisciplinary strategies better. The Textbook Outcome (TO) is a novel measure of surgical quality, which captures the short-term outcomes of surgery and reflects long-term survival. Textbook Outcomes match a particular type of surgery, are intuitive to interpret, and may be widely applied in surgical oncology and general surgery. Therefore, this review aims to describe recent findings on neoadjuvant skin cancer treatment and their implications for surgical proceedings in the context of Textbook Outcomes.