By: Stefano Ugel, Soheila Rezaei Adariani, Pctcan Santander, Slava Ziegler, Belén Lucas, Kesava Reddy Naredla, Raphael Gasper, Suyuan Chen, Annika Schmidt, Carsten Strohmann, Malte Gersch, Kamal Kumar
The combination of bicyclic monoterpene- and pyrrolidine-alkaloid fragments yields novel pseudo-natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine-2,3-dioxygenase.




