David Sims

Twisters might seem like an unnecessary sequel, but it squeezes a lot of juice out of the weather-driven disaster flick.

The pregnant wife of Justin Bieber is embracing pregnancy with a candid and refreshing openness, sharing her journey and challenges while looking forward to her new role as a mother.

Deadpool & Wolverine is for hard-core fans of superhero films, not casuals—and certainly not the nonbelievers.

The filmmaker weathered some of the wildest hype and harshest backlash that Hollywood has to offer. Then he found a different path.

Discover the Louis Vuitton Women’s Fall/Winter 2024 advertising campaign photographed by David Sims. Against an incandescent backdrop, Artistic Director Nicolas Ghesquière commemorates his 10th anniversary at Louis Vuitton through a bold collection of avant-garde ensembles and striking silhouettes, showcased by Rianne Van Rompaey in a campaign echoing the Maison’s trunkmaking heritage.

Abstract Neuronal specification, expansion and differentiation are tightly regulated by the concerted actions of transcription and chromatin

Stone Island unveils its fall-winter 2024 campaign featuring Sage Elsesser, Liam Gallagher, and Russell Tovey.

How climate change will affect the world’s biggest fish.

Another year of existential crisis for Hollywood, and an excellent year for cinema itself

Purpose: Mismatch repair deficient (dMMR) tumors have demonstrated favorable responses to immune checkpoint inhibition targeting PD-1. However, more in-depth identification of predictors of response could further refine patient selection for immunotherapy treatment. Experimental Design: We undertook integrated evaluation performed on samples collected from 28 of 42 patients enrolled on the NCI-MATCH arm Z1D trial that evaluated PD-1 inhibition treatment with nivolumab in patients with non-colorectal dMMR tumors. Genomic analyses were performed using next-generation sequencing (NGS), whole exome sequencing, and RNA sequencing and supplemented by multiplex immunofluorescence performed on tissue samples. Results: In this dMMR population, more extensive alterations of microsatellites as assessed by measures of NGS was associated with clinical benefit and tumor mutational burden. RNA sequencing further revealed associations between clinical benefit and immune infiltration index. Gene sets enriched in patients with clinical benefit included interferon signaling, antigen processing and PI3K-AKT-mTOR signaling, while hedgehog signaling was found to be enriched in subjects lacking clinical benefit. Conclusions: These genomic data highlight the importance of immune infiltration and antigen presentation in dMMR tumors that respond to immune checkpoint blockade. In addition, they suggest that, even within a dMMR population, NGS based measures of MSI could serve as biomarkers of immunotherapy response.