Jing Yang

Empagliflozin Activates the AMPK/SOX4/MUC2 Axis to Restore the Intestinal Mucous Barrier in GSD-IBD. SOX4 maintains goblet cell function and mucin secretion to preserve the mucus barrier under physio...

This work successfully fabricates CS/PEG composite hydrogels through efficient homogenization and crosslinking strategies. The CS network scaffold effectively encapsulates PEG phase change materials,...

Background Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM) and is closely linked to immune and inflammatory dysregulation. Multi-component pharmacological interventions have been explored as complementary approaches for metabolic and immune modulation; however, their effects on DPN and related mechanisms remain incompletely understood. Methods A rat model of T2DM-associated peripheral neuropathy was established, and a multi-component pharmacological intervention (MPCI) was administered for 8 weeks. Peripheral nerve dysfunction was evaluated by motor and sensory nerve conduction velocities (MNCV and SNCV), behavioral outcomes, and histological/ultrastructural assessments. In parallel, spleen tissues were collected for transcriptomic profiling. RNA sequencing was performed to identify differentially expressed genes and immune-related pathways, and representative molecules involved in inflammatory regulation were further validated using western blotting and quantitative real-time PCR in sciatic nerve tissue. Results MPCI administration significantly ameliorated peripheral nerve dysfunction in T2DM rats, as evidenced by improved nerve conduction velocities and pathological features. Transcriptomic analysis of spleen tissue revealed that MPCI was associated with broad remodeling of diabetes-related immune and inflammatory gene programs. In parallel, sciatic nerve analyses showed attenuation of NF-κB/c-Jun–associated inflammatory signaling and modulation of inhibitory regulators at both the protein and mRNA levels. Conclusion These findings indicate that MPCI improves T2DM-associated DPN and is associated with splenic immune remodeling and attenuation of peripheral nerve inflammatory signaling, providing exploratory evidence for associations between splenic immune transcriptomic remodeling and peripheral nerve inflammatory signaling.

Biological skin provides humans with sophisticated tactile perception, enabling precise object recognition and texture discrimination. Inspired by this, iontronic skins have emerged as a high-performance sensing platform that converts mechanical stimuli into electrical signals via the dynamic modulation of e

The U.S. Department of Defense on Monday added more than a dozen Chinese tech companies including Alibaba and Baidu to a blacklist, a move that could further escalate tensions between the world’s two largest economies.Electric vehicle makers Byd and Nio, humanoid maker Unitree, Yangtze Memory Technologies and ChangXin Memory Technologies, China’s two largest memory chip makers, were also

Chinese AI lab DeepSeek has closed its first funding round that raised more than 50 billion yuan ($7.4billion) under an unusual deal structure, according to two people with direct knowledge of the matter. The funding round, which values the large-language model developer at more than $50 ...

Abstract Avian influenza viruses undergo frequent genetic reassortment, which can coincide with phenotypic changes in transmission, pathogenicity, and host species niche.

Affiliations & Notes MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China

The early Chinese backers of AI firm Manus are planning to buy the firm back from Meta Platforms at the $2 billion price Meta paid, in response to a Chinese government order that the deal be reversed, according to two people with direct knowledge of the matter. While the government’s order has ...

The relentless rise of antimicrobial resistance poses a critical threat to global health, urgently demanding the development of antibacterial vaccines. Messenger RNA (mRNA) technology, validated duri...