Kathleen E.

Candles, prayers, tears and tales of tragedy from the fighting. “The things that are coming out of there are brutal,” one man tells the crowd.

In a population-based representative sample of adults residing in 22 communities in Botswana, a southern African country with high HIV prevalence, 1 in 4 individuals had high blood pressure. High blood pressure was less prevalent in adults with HIV than without HIV. Sixty percent of persons with high blood pressure had not previously been diagnosed. Among individuals with a prior diagnosis of high blood pressure who reported being prescribed anti-hypertension medications, almost half had elevated blood pressure, irrespective of HIV-status. One-third of adults in this setting (mainly men) declined free non-invasive blood pressure assessments in their households. In conclusion, our study highlights alarmingly high hypertension rates in the community, with low levels of awareness and control, emphasizing the urgent need for community level BP screening and active management to reach recommended targets.

Abstract Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that

Abstract Humans' ability to adapt and learn relies on reflecting on past performance.

Abstract Retinal prostheses stimulate inner retinal neurons to create visual perception for blind patients. Implanted arrays have many small electrodes.

Harnessing the potential of microbiota analysis creates new opportunities in diagnosing diseases, improving treatment efficacy, reducing treatment complications and preventing disease recurrence. However, microbiota analysis has not yet been integrated into clinical management workflows. Here, we discuss crucial characteristics of microbiota analysis systems for clinical translation.

Abstract Swim tests are highly effective for identifying vestibular deficits in rodents by offering significant vestibular motor challenges

Abstract Cellular responses to stimuli underpin discoveries in drug development, synthetic biology, and general life sciences.

The vestibular system is vital for maintaining stable vision during daily activities. When peripheral vestibular input is lost, patients initially experience impaired gaze stability due to reduced effectiveness of the vestibular-ocular-reflex pathway. To aid rehabilitation, patients are often prescribed gaze-stabilization exercises during which they make self-initiated active head movements. Analyzing statistical pattern of sequences of stereotyped behaviors to characterize degrees of randomness or repeatability has proven to be a powerful approach for diagnosing disease states, yet this approach has not been applied to patients with vestibular loss. Accordingly, here we investigated whether the patterning of head movements is altered in vestibular-loss patients by using trial-based analysis and sample-entropy measurement. The subjects completed gaze-stability exercises in both the yaw and pitch directions. In trial-based analysis, we calculated the trial-to-trial variability of head movement duration and peak velocity for each individual head movement. Our results showed that healthy individuals exhibited a temporally repetitive (correlated) structure in peak velocity, especially for head movements in the pitch direction, which was absent in most patients. In the sample entropy analysis, which measures the irregularity or randomness of a time series, our results revealed that head-movement generation was more regular in vestibular-loss patients compared to healthy controls. Together, these analyses suggest that vestibular-loss patients display less flexibility in the patterning of their head motions. Our results provide the first experimental evidence that temporal head stability is a valuable metric for distinguishing individuals with impaired vestibular function from healthy ones.

A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the progression of breast cancer.