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Michael J. predominantly covers scientific research with a strong emphasis on citing data, particularly in the areas of genetics, neuroscience, and health technology. He would likely be interested in pitches that offer access to or insights from experts involved in groundbreaking scientific studies related to genetics, neuroscience, medical studies, and health technology.
Given Michael's focus on citing data extensively within his articles, he may be interested in receiving pitches from researchers or professionals who can provide unique datasets or analyses relevant to the topics covered. Additionally, individuals with expertise in innovative technologies shaping the healthcare landscape could also capture his attention.
While no specific geographic focus is mentioned for Michael J., it appears that he takes an international view of scientific research across various disciplines within healthcare and technology.
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By: Conor, Michael J., Abrams, Aquilina, Griffiths, Hall, Simon, Mallucci, Kristian
As the leading cause of disability and death in children, paediatric traumatic brain injury (pTBI) is a clinical concern that impacts children on a global scale [1]. The incidence of TBI varies dramatically both between and within countries, ranging between 47 and...
By: Huiming, Yueh-Ju, Liang, Giorgia, Shinyoung, Pengcheng, W. Andy, Michael J., Batelli, Xue, Tao, Lee, Zhu, Hou, Wang, Van Oosten, Zhang
Sucrose nonfermenting 1 (SNF1)-related protein kinase 2s (SnRK2s) are central components of abscisic acid (ABA) signaling pathways. The snrk2.2/2.3...
By: Jeffrey L., Jackson, Lyssiotis, Zhang, Khalid N., Jacob M., Li, Costas A., Bang, Jüri, Leuven, Jocelyn, Wahl, Caldwell, Liddy, Kin, Katie, Masahiro, Teng, Berman, Ricky, Cynthia H., Michael J., Fotiadou, Chiu, David P., Peter, Cook, Tsai, Temel, Andreea, Lowden, Christopher, Elaine, Obersterescu, Daniel R., Stewart, Miguel A., Schramek, Borowsky, Linkang, Colinda L. G. J., Sean E., Mbamalu, Lopes, Larissa, Daniel, Pujana, Parsons, Alexander D., Miguel Angel, Ellen R.
Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity is associated with highly stress-resistant mitochondria and enhanced detoxification of reactive oxygen species.
By: Hiroaki, Jay L., Okae, John D., Ruhul H., Masanaga, Vivian, Choudhury, Varberg, Gibson, Soares, Regan L., Biswell, Elin, Kozai, Muto, Scott, Michael J., Keisuke, Simon, Grundberg, Mikaela E., Aplin, Takahiro, Iqbal, Khursheed, Kaela M., Arima, Margaret, Rebecca
Invasive trophoblast cells are critical to spiral artery remodeling in hemochorial placentation. Insufficient trophoblast cell invasion and vascula...
By: Xue, Vaughan, Junchao, Lulu, Andrew E.,, Gan, Hannah C., Xinyuan, Mitchell, Xu, Michael J., Geisler, Li, Zhao
Macrophages are integral components of the innate immune system, playing a dual role in host defense during infection and pathophysiological states...
By: Omar, Michael J., Oli, Al Sayed Omar, Matthias, Al Hajji, Schmidt
Understanding migration routes, seasonal timing, and movement strategies of long-distance migrants is essential for evaluating population connectivity and informing conservation. The Greater Spotted Eagle (Clanga clanga), a vulnerable raptor, winters in parts of the Middle East, but migration patterns of birds using the northern Arabian Gulf remain poorly documented. Between 2019 and 2025, we used satellite telemetry to track eight Greater Spotted Eagles wintering in wetlands surrounding the head of the Arabian Gulf in Kuwait, Iraq, and Iran. Seven individuals migrated approximately 3,500 km–4,000 km to summering areas in the Kazakhstan–Russia border region east of the Caspian Sea, following migration routes south of the sea during both spring and autumn migration. Eagles showed fidelity to wintering areas across years and typically arrived at wintering grounds in mid-October. Adults departed wintering areas earlier than immature birds during spring migration, whereas differences in migration distance, duration, and daily displacement between age classes were not statistically supported. Stopovers occurred during both spring and autumn migration, and were concentrated primarily in wetland and riparian habitats. These findings provide new evidence of migratory connectivity between the northern Arabian Gulf and Central Asian summering areas, highlight age-related differences in migration timing, and fill an important knowledge gap in the migration ecology of Greater Spotted Eagles using this poorly studied wintering region.
By: Arnett, Olalekan, Michael J., Olukayode, Drew, Aderemi, Joshi
Purpose Tumor-infiltrating lymphocytes (TILs) and proinflammatory biomarkers shape breast cancer (BC) progression and outcomes. We estimated the association between TILs and BC subtypes in Nigerian women and, in exploratory analyses, evaluated relationships between serum biomarkers (IL-6, IL-8, IL-1β, TNF-α, and leptin), TILs and BC subtypes. Methods TILs were quantified on H&E-stained tumors from 436 treatment-naïve Nigerian BC patients, serum biomarkers (n = 109) were profiled by Meso Scale Discovery immunoassays. TILs and proinflammatory biomarkers were assessed across BC subtypes using descriptive analyses and multinomial logistic regression; cytokine ratios were also explored to characterize TNF-α dominance. Results Median age was 49, and subtypes were triple-negative (TNBC, 43%), luminal A (31%), luminal B (12%), and HER2-enriched (15%). Median TIL percentage was 10.0 (Q1, Q3: 4.0, 21.0), with 49% of patients classified as low TIL (< 10%), 41% as intermediate (10- < 40%) and 10% as high (≥ 40%). Compared to low TILs, medium (OR 1.94, 95% CI 1.11–3.38, p = 0.020) and high TILs (OR 2.65, 95% CI 1.00–6.99, p = 0.049) were associated with higher odds of TNBC vs. ER+ after demographic and clinical adjustments. TNF-α correlated with TILs (ρ: 0.21; p = 0.026) and higher TNF-α:IL-1β (OR 4.16, 95% CI 1.35–12.84) and TNF-α:IL-8 (OR 3.81, 95% CI 1.29–11.23) ratios were associated with TNBC but not HER2 (vs. ER+); individual biomarkers were not associated with subtypes. Conclusion Elevated TILs and TNF-α−dominant profiles are associated with TNBC (vs. ER+) in Nigerian women, highlighting potential immunotherapy relevance in Nigerian TNBC cases and a suggestive prognostic/therapeutic role for TNF-α.
By: Ema, Takahiro, Chakraborty, Kaela M., Soares, Ayelen, Varberg, Mcnally, Choudhury, Masatsugu, Shoma, Masanaga, Ross P., Arima, Alan E., Regan L., D., Okae, Muto, Damayanti, Aplin, Scott, Irusta, Ruhul H., Moreno, Matsumoto, Hiroaki, Elin, Khursheed, Mast, Grundberg, Iqbal, Michael J.
Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilize...
By: Nina A., Manning, Hawkins, Brendan J., Katherine S., Salem, Chevalier, Toumy, Yang, Dawn R., Daniel P., Guettouche, Mattoon, Zabroski, Michael J., Grimes, Brittany, Aaron, Timothy, King, Troy B., Smith, Fernandes, Barcaskey, Gabrielle N.
Tumor-derived extracellular vesicles and particles (EVPs) represent a promising analyte class for early cancer detection. However, discrimination of tumor-derived EVPs from those shed by healthy tissues represents a major analytical challenge. This work describes the design and characterization of a novel proximity ligation-based immunoassay which targets tumor-derived EVPs in plasma displaying four colocalized surface biomarkers. We demonstrate the functionality of this approach in cancer cell line-derived EVPs and apply the method to lung adenocarcinoma (LUAD) detection. Importantly, we find that requiring four colocalized cancer-associated biomarkers reduces interference from healthy EVPs versus a three-biomarker design, resulting in strong discrimination performance for several biomarker combinations. Using this approach, we developed a prototype assay for LUAD detection which was evaluated in a case-control study composed of 92 LUAD cases and 290 non-cancer controls. The assay and trained classifier exhibited 48.5% (33/68; 95% confidence interval (CI) 37.1–60.2%) stage I sensitivity, 83.3% (15/18; 95% CI 59.8–94.8%) stage II sensitivity, and 100% (6/6; 95% CI 55.2–100%) stage III/IV sensitivity at 90% specificity. Assay signal was significantly correlated with tumor size and uncorrelated with smoking history. These preliminary results demonstrate the technical feasibility of this platform for early-stage lung cancer detection.
By: Cynthia, Michelle, Audrey, Lucia, Dalton, Sufi, Dionisi, Jo, Pawan, Montorsi, Michael J., Gibbons, Paul, Bishop, Kleeman, Richard J., Ellis, Spencer
Developing transitional T2 B cells express differing levels of surface IgM. Here, the authors analyze epigenome and transcriptome dynamics in IgMhi and IgMlo T2 cells and find differences propagating from T2 cells to naïve and memory cells or to marginal zone B cells, demonstrating early lineage bifurcation to shape B cell maturation.
