Mohammad Reza

Abstract Background The evaluation of genetic mutations is crucial for personalized therapy in colorectal cancer (CRC), but the

Abstract Objectives This study aimed to evaluate the individual and combined effects of silver nanoparticles (AgNPs), zinc oxide

Delayed planting after rice harvest constrains maize productivity in Sari. Appropriate planting dates are one of the most important factors in determining the yield potential of crops, and methanol and glycine betaine usage is a suitable solution to reduce the effects of delayed cultivation. For this purpose, a factorial research was carried out in the form of Randomized Complete Block Design (RCBD) with three replications in two years (2020–2021) in Sari, Mazandaran, Iran, on maize as a second planting after rice harvest. Treatments included glycine betaine at three levels [0 (control), 1, and 2 ppm], methanol at three levels [0 (control), 10, and 20% v/v], and three planting dates: [August 6, 16, and 26]. The results illustrated that the significant differences between planting date, glycine betaine and methanol. The application of methanol and glycine, as well as increasing the concentration of methanol (20% v/v) and glycine betaine (2 ppm), improved the yield and forage quality of maize. The delay in maize cultivation (August 26) decreased the yield and forage quality of maize. The best planting date for corn cultivation was August 6. Foliar spraying of methanol and glycine reduced the negative effects of delayed planting dates compared to the control. Methanol 20% v/v + glycine betaine 2 ppm on the planting date of August 6 raised dry matter yield (81.34%), water-soluble carbohydrates (96.58%), dry matter digestibility (21.63%), acid detergent fiber (50.32%), and neutral detergent fiber (39%) compared to the control of methanol and glycine on August 26. Overall, in order to achieve maximum yield and forage quality of maize, foliar spraying of methanol 20% v/v along with glycine 2 ppm on the August 6 planting date is recommended.

Background Paraquat poisoning is one of the most lethal toxicological emergencies, particularly in low- and middle-income countries. Despite several proposed treatment regimens, no single approach has conclusively demonstrated a reduction in mortality. Early clinical manifestations may be nonspecific, and prompt recognition in the emergency department is critical. We report the unexpected survival of a young woman who ingested a potentially fatal dose of paraquat, with emphasis on long‑term radiological follow‑up and dynamic hematological changes. Case presentation A 22‑year‑old Iranian woman presented to the emergency department approximately 48 h after reportedly ingesting 20 mL of a 20% paraquat solution in a suicide attempt. She had initially been evaluated at another facility shortly after ingestion but had refused admission against medical advice. She developed oropharyngeal mucosal ulcerations, odynophagia, hemoptysis, and acute kidney injury (peak serum creatinine 3.9 mg/dL). Laboratory data revealed a triphasic white blood cell pattern, including profound leukopenia followed by a marked rebound after granulocyte colony‑stimulating factor (G‑CSF) administration. A chest CT obtained at admission showed no pulmonary involvement; however, a follow-up CT performed on Day 14 demonstrated diffuse bilateral ground‑glass opacities and patchy consolidations consistent with acute alveolar injury. The patient received early multidisciplinary management including high‑dose corticosteroids, cyclophosphamide, antioxidant therapy, broad‑spectrum antibiotics, antimicrobial prophylaxis against opportunistic infections, nutritional support, and electrolyte correction. Clinical improvement was observed within 72 h, and she recovered without requiring dialysis or mechanical ventilation. A six‑month follow‑up chest CT showed complete radiological resolution with no evidence of pulmonary fibrosis. Conclusions This case suggests that complete pulmonary and renal recovery may be achievable in clinically severe paraquat poisoning. The six‑month imaging follow‑up documents the complete resolution of acute lung injury, while the dynamic leukocyte pattern illustrates the severity of bone marrow suppression and subsequent recovery. These findings highlight the potential value of early recognition, intensive multidisciplinary management, and structured follow‑up, particularly in resource‑limited settings.

Background and aim Considering the growth of the elderly population in Iran and the prevalence of cognitive and physical illnesses among them, identifying strategies to enhance subjective vitality and a sense of purpose in life is crucial. This study aimed to evaluate the effect of group poetry reading on meaning in life and subjective vitality in older adults attending a daycare center. Methods In this clinical trial study, 73 older adults who visited a daycare center were enrolled and randomly assigned to an intervention group (n = 37) or a control group (n = 36). The intervention group participated in 60–90-minute group poetry sessions twice weekly for 6 weeks, while the control group attended the regular programs in the center. Both groups completed the Subjective Vitality Scale and Meaning in Life Questionnaire pre- and post-intervention. The data collected were analyzed using ANCOVA, independent t-tests, and paired t-tests in SPSS version 22. Results Post-intervention, a significant difference was observed between groups in meaning in life (p = 0.031), with higher scores in the intervention group (60.02 ± 7.15 vs. 53.55 ± 6.88). For subscales, the intervention group showed significantly greater improvement in “search for meaning” (p = 0.009) but not in “presence of meaning” (p = 0.339). Both groups exhibited increased subjective vitality post-intervention (intervention: p = 0.046; control: p < 0.001), but no significant difference between groups emerged (p = 0.377). Conclusion The results of this study showed that holding group poetry reading sessions can promote meaning in life, especially in the domain of “searching for meaning” among the elderly. But results showed no significant difference between the two groups’ Subjective Vitality mean scores after the intervention. Therefore, holding such classes in elderly day care centers or nursing homes are recommended to improve meaningful life in the elderly. Trial registration IRCT20190727044347N7 (Registration date: 04/12/2024).

Reinforcement corrosion is a primary cause of durability loss and structural degradation in reinforced concrete (RC) structures.

This study investigates and compares the sustainability of autumn and spring sugar beet production systems in Khorasan Razavi Province using emergy indicators.

Background Bovine mastitis is one of the most common and important inflammatory diseases that has significant implications in the dairy industry, in terms of both animal welfare and economic aspects. Transposable elements (TEs), a major component of the eukaryotic genome, were once thought to have little or no function/activity, but recent studies have shown the significance of TEs in different diseases, particularly their potential to modulate immune responses. However, the contribution of TEs to mastitis remain largely unknown. Furthermore, cell-type–specific patterns related to TE transcripts have not been reported in bovine mastitis. Methods Here, single-cell RNA sequencing employed to profile the expression patterns of TEs in 27,729 cells derived from bovine peripheral blood mononuclear cells, cultured in vitro before and after LPS stimulation. Through a systematic single-cell investigation, seven major cell-types were identified that were used to investigate the contribution of TEs to the regulatory mechanisms involved in the immune response of cells to LPS-induced mastitis. Results The findings revealed that TEs contribute to cell heterogeneity, emphasizing their potential as biomarkers. We found TE loci that exhibited cell-type specific expression patterns and were also overlapped with genes related to function of that cell-type. Interestingly, we observed a striking pattern, in which the mean expression of TEs across all cell-types were increased in LPS-treated samples than control, especially in T, B and HSC/MPP cell-types, which are the main players of the immune system. This pattern revealed that the activation of TEs may mediate cells to immune response to infection. Moreover, several examples were found in which expression of TEs have been significantly and positively linked to expression of neighboring genes, supporting the extensive contribution of TEs during mastitis. Interestingly, most of the TE-gene pairs whose expression were significantly associated, were those that were reported to be involved in mastitis or immune response such as BOV-A2, Bov-tA2, MIR3, MIRb, L2a, PAX5, IL1RN, GRB2, CCR7, NFKBIE, EPSTI1, ZEB2, IRF8, CD22 and STIM1. Conclusions Our study shows the potential of TEs as important mediators of immune system whereby can contribute to coordinated transcriptional responses during infection and act as major drivers of disorders such as mastitis.

Great-power rivalry has been one of the most thought-provoking and controversial issues in international relations since ancient times. Transition and shifting power have always posed debates among scholars and researchers. Currently, competition between the U.S. and...

Althaea officinalis is a medicinal plant, rich in mucilage and polyphenols and traditionally used to relieve inflammation and irritation of respiratory, digestive, and urinary tissues.