Steve White

The Mondrian Hong Kong, close to the famous Victoria Harbour, offers an artsy, eclectic alternative to a cookie-cutter stay

Headed to Formosa on business? If you like outdoor adventure, Taiwan has plenty, so be sure to pack your gear and add time to your trip

Grand Island’s new casino wants to add uniformed police officers.The Grand Island City Council is being asked to approve a five-year contract with Grand Island Casino Resort.Under the agreement, uniformed officers would be allowed to work overtime shifts at the casino when staffing allows.

Elizabeth “Liz” Bryan, a fairly new member of the Bucks County Roadrunners Club, lit up the distaff field this past season in the recently completed Winter Series.

New champions were crowned at the Puravida-MiPost Welsh National Surfing Championships 2026 at Freshwater West last weekend.

Volunteers stepped in to help producers rebuild after damaging storms swept through parts of central Nebraska.

I moved to Baytown from Houston, over four years ago. There are so many things I like about Baytown. One of the things I like most is the nature of the neighborhoods: smaller, more friendly and quiet. Now there is something threatening our neighborhoods –– allowing, no, encouraging –– short-term rental of residential property. As many cities in Texas are moving to prohibit short-term home rentals in residential neighborhoods, Baytown is looking to give carte blanche to them. This would be a mistake of epic proportions.

Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3–6, 2026. This article provides summaries of eight treatments in preclinical and early clinical development that were presented at EILAT XVIII. These include AUT00206, a positive allosteric modulator of Kv3.1 and Kv3.2 voltage-gated potassium channels in development for the treatment of rare epilepsy syndromes as well as neurodevelopmental and neuropsychiatric disorders; ION283, an antisense oligonucleotide designed to suppress the expression of glycogen synthase 1, under investigation for the treatment of Lafora disease; MSCA-7136, a selective allosteric RAS/mitogen-activated protein kinase—extracellular signal regulated kinase (MEK) inhibitor being developed for the treatment of focal seizures associated with mesial temporal lobe epilepsy and seizures associated with tuberous sclerosis complex; OV329, a selective inhibitor of γ-aminobutyric acid (GABA) aminotransferase, in development for the treatment of drug-resistant focal seizures; PTI5803 (probenecid), an uricosuric agent and a blocker of pannexin 1 channels, repurposed as a treatment for seizures associated with focal cortical dysplasia; simufilam, a filamin A modulator under investigation for the treatment of tuberous sclerosis complex-related epilepsy; SN-2000, a selective allosteric phosphodiesterase 4B inhibitor, in development for the treatment of focal seizures; and sodium selenate, a promoter of the dephosphorylation of pathological hyperphosphorylated tau in the brain, under investigation as a disease-modifying agent in mesial temporal lobe epilepsy. Treatments in more advanced clinical development are discussed in an accompanying article.

This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026. The treatments reviewed include bexicaserin, a selective 5-hydroxytryptamine (5-HT, serotonin) type 2C (5-HT

I remain sorely disappointed with the Baytown City Council vote on July 9.