Tung Nguyen

The full-sized F-150 has received a downgraded Gross Combination Mass (GCM) figure after Ford decided to account for downball weight in calculations.

Here is every new or updated model eligible for the Drive Car of the Year 2025 – Best Family Car Under $80K category.

If you think a large seven-seat SUV is the ultimate family car, the Kia Carnival presents a convincing alternative.

Road safety blitz follows Queensland recording increased rates of e-scooter accidents over the past three years.

Vistiq large electric SUV could join Lyriq in Cadillac Australia showrooms as the premium brand looks to bulk out its line-up.

The transcriptional repression of alternative lineage genes is critical for cell fate commitment. Mechanisms by which locus-specific gene silencing is initiated and heritably maintained during cell division are not clearly understood. To study the maintenance of silent gene states, we investigated how the Cd4 gene is stably repressed in CD8+ T cells. Through CRISPR and shRNA screening, we identified the histone chaperone CAF-1 as a critical component for Cd4 repression. We found that the large subunit of CAF-1, Chaf1a, requires the N-terminal KER domain to associate with the histone deacetylases HDAC1/2 and the histone demethylase LSD1, enzymes that also participate in Cd4 silencing. When CAF-1 was lacking, Cd4 derepression was markedly enhanced in the absence of the de novo DNA methyltransferase Dnmt3a but not the maintenance DNA methyltransferase Dnmt1. In contrast to Dnmt1, Dnmt3a deficiency did not significantly alter levels of DNA methylation at the Cd4 locus. Instead, Dnmt3a deficiency sensitized CD8+ T cells to Cd4 derepression mediated by compromised functions of histone-modifying factors, including the enzymes associated with CAF-1. Thus, we propose that the heritable silencing of the Cd4 gene in CD8+ T cells exploits cooperative functions among the DNA methyltransferases, CAF-1, and histone-modifying enzymes.

Ford says there's room in the Ford showroom for both the Ranger Super Duty and upmarket F-150.

Major disruptions and increased traffic congestion are expected in Melbourne as a major freeway closure is announced ahead of Christmas.

The replacement to Motorclassica is running at Melbourne Showgrounds from 22 November to 24 November.

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