Ana María

by José María Romero Otero Luis Nieto Roca Ana María Pello Lázaro and Department of Cardiology, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain

Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública México, Av. Universidad 655 Santa María Ahuacatitlán, Cuernavaca 62100, Morelos, Mexico

This study aimed to evaluate the effects of several minor components of extra virgin olive oil (EVOO) on platelet thromboxane and vascular prostacyclin production in rat aortic rings under high-glucose conditions (300 mg/dL), in relation to their potential antioxidant actions. Under hyperglycaemic conditions, thromboxane production was 1.3 times higher, while prostacyclin production was 40.9% lower than in samples with 100 mg/dL glucose in aortic rings, accompanied by marked oxidative stress (65.6% higher than in samples with 100 mg/dL glucose). The compounds tested inhibited thromboxane production in a concentration-dependent manner, with relative potencies (secoiridoid derivatives (IC50 range: 10−6 M) = triterpenes (10−6 M) > alcoholic phenols (10−5 M for hydroxytyrosol and 10−4 M for the rest)), while preserving prostacyclin production (5–20% inhibition). All compounds also exerted vascular antioxidant effects, reducing oxidative stress markers and enhancing antioxidant parameters (IC50 range: 10−6–10−5 M), and these effects were observed under both normoglycaemic (100 mg/dL) and hyperglycaemic (300 mg/dL) conditions.

Defective proteostasis is a hallmark of aging cells and tissues. Among the different components of the proteostasis network, in this study, we focu...

by Ana María Montserrat Gala and Nursing Department, Escola Universitària Gimbernat, Adscrita a Universitat Autònoma de Barcelona, 08174 Sant Cugat del Vallès, Spain

Department of Medical Oncology, Ramon y Cajal University Hospital, 28034 Madrid, Spain Department of Medical Oncology, Vithas La Milagrosa University Hospital, 28010 Madrid, Spain

Background Frailty is a multidimensional syndrome associated with increased vulnerability to stressors, chronic disease exacerbations, hospitalizations, and disability. Polypharmacy, often defined as the chronic use of five or more medications, is closely and bidirectionally related to frailty. In this context, medication review is a potential strategy to improve health outcomes and slow down the frailty process by optimizing pharmacological treatments. This study aims to evaluate the impact of a geriatrician-led medication review, integrated within primary care (+ AGIL Barcelona program) on polypharmacy and medication adequacy in older adults. Methods We evaluated the effect of the + AGIL Barcelona program on medication adequacy. The + AGIL is a multidisciplinary and multicomponent intervention aimed at promoting healthy aging, based on a comprehensive geriatric assessment and a 10–week structured exercise program, nutritional counseling, medication review, and healthy lifestyle promotion tailored to the individual's needs. Based on patient’s frailty status, comorbidities, and preferences, geriatricians revised the medications, and the modifications were discussed with the participants’ primary care physician, and in selected cases, with a clinical pharmacist. Baseline and three-month follow-up data were collected, including quantitative polypharmacy prevalence, and potentially inappropriate medications (PIMs), according to the EU(7)-PIM list. Subgroup analyses were based on Clinical Frailty Scale scores. Results The study included 173 community-dwelling older adults (mean age: 81.2 years – SD: 5.7; 68.8% women). At baseline, polypharmacy was prevalent (84.4%), with 59.5% of participants receiving at least one PIM. After three months, a slight reduction in the mean number of medications per patient was observed (7.6 to 7.4, p = 0.051). Reduction of number of PIMs was also observed (1.0 to 0.9 per patient, p = 0.011), particularly in those medications affecting the nervous (from 30.1% to 24.3% in the sample, p = 0.025) and genitourinary (from 6.9% to 4.6%, p = 0.046) systems. After stratifying by frailty, a consistent trend was observed overall and especially among non-frail and vulnerable groups. Conclusions While the + AGIL Barcelona program had a limited quantitative impact on polypharmacy, it significantly reduced PIMs’ use, particularly in nervous system-acting medications, which are involved in increased risk of falling and cognitive impairment in older adults. The study highlights the importance of medication review in multidimensional frailty management, although future research with larger samples and standardized medication review protocols is needed.

Aleida Rosquete-Estevez Júlia Crespin Luis Yubero Ana María Mancho and Marta Umbert