John T.

The most recent (eighth) edition of the American Joint Committee on Cancer (AJCC) staging system divides invasive cutaneous melanoma into two broad groups: “low-risk” (stage IA–IIA) and “high-risk” (stage IIB–IV). While surveillance imaging for high-risk melanoma patients makes intuitive sense, supporting data are limited in that they are mostly respective and used varying methods, schedules, and endpoints. As a result, there is a lack of uniformity across different dermatologic and oncologic organizations regarding recommendations for follow-up, especially regarding imaging. That said, the bulk of retrospective and prospective data support imaging follow-up for high-risk patients. Currently, it seems that either positron emission tomography (PET) or whole-body computerized tomography (CT) are reasonable options for follow-up, with brain magnetic resonance imaging (MRI) preferred for the detection of brain metastases in patients who can undergo it. The current era of effective systemic therapies (ESTs), which can improve disease-free survival (DFS) and overall survival (OS) beyond lead-time bias, has emphasized the role of imaging in detecting various patterns of EST response and treatment relapse, as well as the importance of radiologic tumor burden.

Abstract In biogeochemical phosphorus cycling, iron oxide minerals are acknowledged as strong adsorbents of inorganic and organic phosphorus.

Access through your institution Buy or subscribe The field of Neonatal Hemodynamics evolved to provide longitudinal physiology-based

School of Exercise Science, Physical, and Health Education, University of Victoria, Victoria, BC V8P 5C2, Canada

Testicular germ cell tumor (GCT) is the most common malignancy in 18- to 40-year-old men. Unlike most other cancers, GCT is frequently curable even when metastatic. These tumors can be classified histologically into seminoma and non-seminoma, which determines treatment. Therefore, successful treatment requires accurate diagnosis, classification, and monitoring. Serum tumor markers, including lactate dehydrogenase, α-fetoprotein, and β-human chorionic gonadotropin, aid in the classification and staging of GCTs. These markers therefore play a critical role in the decision-making process when managing GCT patients. However, there exist many scenarios in which these markers fail to perform adequately. This is particularly true in the case of seminoma, where only 10% to 15% will have elevated serum tumor markers. Non-specific elevation of these markers is also a common occurrence, complicating the interpretation of borderline positive results, particularly in follow-up. To bridge this gap in performance, next generation biomarkers are being investigated. In this review, we consider the role of conventional serum tumor markers in GCT management and discuss recent advances in the next generation of biomarkers, with a focus on circulating microRNAs. We discuss the value that circulating microRNAs could bring as an addition to currently used markers, as well as potential weaknesses, in GCT management.

Abstract In naive individuals, sensory neurons directly detect and respond to allergens, leading to both the sensation of itch and the

Abstract During drought, resource managers want to know when the drought will end to make informed management decisions.

The use of membrane-forming curing compounds on fresh concrete has been widely adopted by many States' Departments of Transportation as it is feasible where there is a deficiency of water, on sloping surfaces where curing with water is challenging, and in cases where large areas like pavement have to be cured. However, the evaluation of the curing compound application effectiveness is difficult because most of the evaluation test methods are not performed during the early age of the concrete. Moreover, the ASTM C156 standards test of water retention for the qualification of curing compounds has met criticism as the moisture retention is performed only on the mortar specimens, with a fixed application rate and curing condition. Therefore, in this study, the embedded resistance technique was used as a test replacement for the moisture retention test to assess concrete curing. The findings from this study showed that a correlation can be found between the moisture retention test and the embedded resistance test. Based on the findings, the embedded resistance test could be a suitable replacement for the moisture loss test, because the test is much simpler and quicker to be performed both in the lab and in the field.

Abstract Over the last four decades (1980–2020), the summer westerlies that prevail in South Asia along the monsoon trough region have weakened by about 25% based on multiple reanalysis datasets.

An innovative solution for real-time monitoring of reactions within confined spaces, optimized for Raman spectroscopy applications, is presented. This approach involves the utilization of a hollow-core waveguide configured as a compact flow cell, serving both as a conduit for Raman excitation and scattering and seamlessly integrating into the effluent stream of a cracking catalytic reactor. The analytical technique, encompassing device and optical design, ensures robustness, compactness, and cost-effectiveness for implementation into process facilities. Notably, the modularity of the approach empowers customization for diverse gas monitoring needs, as it readily adapts to the specific requirements of various sensing scenarios. As a proof of concept, the efficacy of a spectroscopic approach is shown by monitoring two catalytic processes: CO2 methanation (CO2 + 4H2 → CH4 + 2H2O) and ammonia cracking (2NH3 → N2 + 3H2). Leveraging chemometric data processing techniques, spectral signatures of the individual components involved in these reactions are effectively disentangled and the results are compared to mass spectrometry data. This robust methodology underscores the versatility and reliability of this monitoring system in complex chemical environments.