Kristen Lee

There's the 911 Dakar—and then there's this new RUF Rodeo, a truly exotic off-road sports car.

MotorTrend caught up with the F1 champion at the 2024 Rolex Monterey Motorsports Reunion to chat things old and new.

MotorTrend Finding the best family vehicle is tough. There are so many top picks in addition to all the considerations you have to make for both you and your loved ones.

Kristen Lee, MotorTrend Staff | MotorTrend Finding the best family vehicle is tough.

From Ford to Mazda, Toyota, Subaru, and VW, hot hatchbacks are special treats that happen once in a blue moon.

Neuroinflammation is involved in the pathogenesis of almost every central nervous system disorder. As the brain’s innate immune cells, microglia fine tune their activity to a dynamic brain environment. Previous studies have shown that repeated bouts of peripheral inflammation can trigger long-term changes in microglial gene expression and function, a form of innate immune memory.

On paper at least, the Sorento and Santa Fe are strikingly similar. Drive both, though, and one decisively emerges as the smarter pick.

In the last three decades, gene therapy has demonstrated significant progress. Over 700 active investigational new drug (IND) applications have been reported. Research on in utero gene therapy has advanced, but ethical and safety concerns persist. A novel approach under investigation is placental gene therapy, which holds promise for targeting diseases associated with placental dysfunction, such as fetal growth restriction (FGR) and preeclampsia. One of the underlying causes of placental insufficiency in these conditions is reduced placental growth factor-driven angiogenesis and endothelial cell dysfunction during fetal development. Studies have explored the overexpression of growth factor transgenes like IGF-1 to address FGR, yielding promising outcomes in animal models. Furthermore, intra-placental gene transfer, instead of systemic delivery of gene therapy vectors, has the potential to treat and cure these disorders. However, challenges and limitations akin to in utero gene therapy persist, including the risk of in utero infection, potential impairment of the mother's future fertility, the risk of germline integration, and possible off-target effects of gene transfer in the fetus or the mother. Consequently, additional research and deliberation within the scientific and medical communities are warranted to fully comprehend the potential benefits and risks of placental gene therapy.

The SUV version of the Hummer EV frequently gets in its own way, with prodigious mass and ungainly proportions, but it’ll make you smile regardless.