Rajesh Kumar

Author(s) Dr. Vaishnavi Prashant Deshpande Prof. Dr. Rajesh Kumar Prof. Dr. Sunil Kumar MV. Dr. Rhythm Saxena Dr. Krishan Kumar Dr. Diksha Verma

Sustainability a business necessity as global tensions hit packaging industry — Rajen Bhagyoday

Tension erupted at Mumbai's Mira Road ahead of Bakrid after a dispute over goats brought to the Poonam Estate Cluster 1 society escalated into clashes. The controversy began after residents objected to a temporary shed allegedly built for keep goats for sacrifice.

Author(s) Dr. Vaishnavi Prashant Deshpande Prof. Dr. Rajesh Kumar Prof. Dr. Sunil Kumar MV. Dr. Rhythm Saxena Dr. Krishan Kumar Dr. Diksha Verma

India’s converters find strength in coexistence Share Facebook X WhatsApp Linkedin Gravure Coexistence of Flexo and Gravure

Focus on consumer experience at Interpack 2026 Share Facebook X WhatsApp Linkedin V-Shapes V-Shapes' booth at interpack 2026.

Mumbai CNG price hiked by Rs 2, now costs Rs 86 per kg; PNG rates also increased

Speciality products generate visitor interest — Sanjay Agarwal

Background Colistin, a last resort antibiotic for multidrug resistant gram-negative infections, is facing enhanced resistance. Data from Eastern India, including Odisha, is limited, highlighting the importance for enhanced surveillance to monitor emerging resistance and guide appropriate empirical therapy. Objective This study aimed to screen for colistin resistance and to evaluate the antimicrobial susceptibility patterns among gram-negative bacteria isolated from clinical samples. Method The study period was from February 2024 to January 2025, during which 366 non-duplicate identified clinical samples were collected from SUM hospital, Bhubaneswar. Antimicrobial susceptibility testing, including colistin tested at three concentrations (10, 25, and 50 µg), was performed using the Kirby–Bauer disk diffusion method. As CLSI and EUCAST guidelines do not recommend disk diffusion for colistin due to poor agar diffusion, the results were considered screening-only and were not used to determine confirmed susceptibility or resistance, and mcr-1 to mcr-9 genes were screened by PCR; however, mcr-1, mcr-3, and mcr-4 were not detected in any of the isolates. Descriptive statistics, including percentages and 95% confidence intervals, were used to summarize prevalence and screening-based colistin non-susceptibility findings. Result Most frequently isolated organisms were E. coli (36.88%) and K. pneumoniae (19.67%). Screen-positive colistin non-susceptibility was observed highest in K. pneumoniae (59.72%), P. aeruginosa (29.62%) and E. coli (8.14%). Multiple mcr genes were detected among screen-positive isolates, with K. pneumoniae positive for mcr-2, 5, 6, 7, 8, 9, E. coli was positive for mcr-5 and mcr-8, A. baumannii for mcr-2, 6, 7 and mcr-1, mcr-3, and mcr-4 were absent in all isolates; P. aeruginosa harboured mcr-7 & mcr-9 only. K. pneumoniae, E. coli and A. baumannii showed high multidrug resistance patterns. These findings are based on screening-positive results only. Prevalence estimates of screening-based colistin non-susceptibility were interpreted descriptively, and 95% confidence intervals were calculated for bacterial isolates and clinical sample sources where appropriate. Conclusion This study highlights screen-positive colistin non-susceptibility among gram-negative isolates in Odisha, India. These screening-based observations underscore the need for confirmatory testing using broth microdilution and ongoing molecular surveillance.

In the last few years, many pharmaceutical companies have shared publicly Net Zero goals aligned with Paris agreement in order to curve climate change and deliver greener medicines to patients. To achieve these ambitious objectives, embedding green and sustainable chemistry concepts into drug development str