Sandeep Kumar

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IntroductionSpirometry, the standard diagnostic tool for obstructive airway disease (OAD), is limited by effort dependency and poor sensitivity for small airways dysfunction. The forced oscillation technique (FOT) provides a non-invasive, effort-independent physiological assessment. This study aimed to evaluate the baseline physiological correlation between FOT and spirometry indices in suspected OAD and assess the role of FOT in patients unable to perform spirometry.MethodsThis cross-sectional observational study enrolled 201 patients presenting with clinical suspicion of OAD at a tertiary care pulmonology department. All participants underwent FOT and spirometry with post-bronchodilator assessment. Airflow obstruction and bronchodilator responsiveness on spirometry were defined as per European Respiratory Society/American Thoracic Society (ERS/ATS) guidelines. FOT abnormalities and bronchodilator responsiveness were interpreted using previously published literature-based thresholds for oscillometric parameters. Body plethysmography was additionally performed. Patients were stratified into three groups: Group A, obstruction on both spirometry and FOT, n=135 (67.2%); Group B, normal spirometry with obstruction on FOT, n=57 (28.4%); and Group C, unable to perform spirometry with obstruction on FOT, n=9 (4.5%). Statistical analysis was performed using SPSS version 24.0.ResultsFOT peripheral indices, particularly AX, X5, and R5-R20, showed the strongest correlations with percentage of predicted forced expiratory volume in one second (FEV₁%). Bronchodilator responsiveness was highest in Group B. FOT parameters worsened progressively with increasing obstruction severity, and percentage changes in FOT indices after bronchodilator administration correlated strongly with FEV₁% change.ConclusionFOT demonstrated excellent feasibility and identified airway obstruction in patients with preserved spirometry, supporting its complementary role in the physiological assessment of OAD. Peripheral oscillometry indices serve as valuable markers of small airways dysfunction and bronchodilator responsiveness.

The present study explores the thermodynamic and molecular interaction behaviour of l-threonine and its dipeptide glycyl-l-threonine in aqueous solutions of the ionic liquid 1-octyl-3-methylimidazolium bromide [OMIm][Br] across a temperature range of 288.15–318.15 K. Accurate measurements of solution density and ul

UPPCL approves ₹ 162 crore for power projects in four districts, including new substations, high-tension lines, and transformer enhancements for improved electricity supply.