Yan Wang

Abstract Volatile organic compounds (VOCs) are common constituents of fruits, vegetables, and crops, and are closely associated with their

Whether the addition of aromatase inhibitors (AIs) to recombinant human growth hormone (rhGH) could yield additional benefit for short stature is controversial. We aimed to assess the effects of combined AIs and rhGH versus those of rhGH alone for short stature using a meta-analytic approach. The PubMed, Embase, and the Cochrane library electronic databases were searched systematically for eligible randomized controlled trials (RCTs) from inception until December 2021. The pooled effect estimates (weighted mean difference [WMD] and odds ratio [OR]) with 95% confidence intervals (CIs) were calculated using a random-effects model. Eight RCTs that provided data on 433 participants were selected. The addition of AIs to rhGH, compared with rhGH alone, resulted in higher growth velocity (WMD: 3.19 cm/year; 95% CI: 2.75–3.63; P < 0.001), higher predicted adult height (WMD: 5.50 cm; 95% CI: 3.52–7.49; P < 0.001), and younger bone age (WMD: -0.80 years; 95% CI: -1.06–-0.54; P < 0.001). There were no significant differences between the groups for insulin-like growth factor I (WMD: 0.85 nmol/L; 95% CI: -2.08–3.79; P = 0.569), serum estradiol level (WMD: -19.19 pmol/L; 95% CI: -46.25–7.88; P = 0.165), and serum testosterone level (WMD: 14.88 nmol/L; 95% CI: -14.13–43.88; P = 0.315). There was no significant difference between the groups for the risk of adverse events (OR: 1.08; 95% CI: 0.44–2.66; P = 0.873). This study found that the addition of AIs to rhGH had greater benefits for growth velocity, predicted adult height, and bone age. The safety profiles were comparable.

Osteosarcoma (OS) is the most common malignant bone tumor, characterized by a high propensity for metastasis. Recent studies have highlighted the role of alternative splicing in cancer metastasis, although the precise mechanisms underlying aberrant splicing in OS invasion and metastasis remain unclear. Here, we analyzed consistently differentially expressed genes and differentially alternative splicing events between primary and metastatic OS to identify potential genes associated with OS progression. U1 small nuclear ribonucleoprotein 70K (

There is a lack of research examining the association between obesity and depressive symptoms in relation to mental health. This study aimed to examine the correlation between Body Roundness Index (BRI) and depressive symptoms in elderly Chinese individuals.

To analyze the effect of sJAM-C on coronary artery stenosis, and to verify whether sJAM-C could be a biomarker for coronary artery stenosis

Abstract The NLRP3 inflammasome is an intracellular protein complex that causes inflammation via the release of IL-1β and pyroptosis.

Using the high-time-resolution data from the Magnetospheric Multiscale mission, precursor waves upstream of foreshock transient (FT) shocks are statistically investigated using the four-spacecraft timing method. The wave frequencies and wave vectors determined in the plasma rest frame (PRF) are shown to follow the cold plasma dispersion relation for whistler waves. Combining with the feature of the right-hand polarization in the PRF, the precursors are identified as whistler-mode waves around the lower hybrid frequency. The occurrence of whistler precursors is independent of the Alfvén Mach number and the FT shock normal angle. More importantly, all the whistler precursors have group velocities pointing upstream in the shock frame, suggesting the dispersive radiation to be a possible generation mechanism. The study improves the understanding of not only the whistler precursors but also the overall FT shock dynamics.

The n -dimensional complete Josephus cube \(CJC_n\) is the edge-augmented Josephus cube suitable for massively parallel processing systems.

This paper discusses the progress, practices, and action framework employed by banks to reduce and eliminate coal exposure. It introduces a three-step framework designed to guide banks in establishing procedures that can also be applied to other fossil fuels. The paper recommends that Chinese banks strategically manage global coal relationships and collaborate internationally. By detailed planning and sustained efforts, Chinese banks can gain a competitive edge from coal exit.

Funding: This work was supported by the National Natural Science Foundation of China (Nos. 81874360 and 82374117); the Major Natural Science Research Projects of Anhui Province Colleges and Universities, Grant/Award Number: KJ2021ZD0060; and the Excellent and Top Talents Cultivation Project of Anhui Province Colleges and Universities, Grant/Award Number: gxbjZD2022026. Jing Xu and Yulong Zhu contributed equally to this work.