Jose Antonio

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Chimeric antigen receptor (CAR) T-cell therapy has a remarkable impact on the outcome of pediatric and young adult patients with relapsed/refractory

Abstract TET-family members play a critical role in cell fate commitment. Indeed, TET3 is essential to postnatal development due to yet unknown reasons.

Background: Adolescence is a critical period for developing self-perception, emotional well-being, and health behaviors. Mental health disorders represent a substantial burden for adolescents worldwide. This study examines self-perceived health, mood, and substance use among adolescents, identifying associated risk factors. Method: A cross-sectional study was conducted with 121 adolescents aged from 14 to 18 from a secondary school in Baix Llobregat, Catalonia. Data were collected through questionnaires, and descriptive and comparative analyses were performed. Results: Poor self-perceived health and negative mood were associated with higher alcohol and tobacco use. Girls exhibited better emotional regulation than boys. Conclusions: Poor health perception and negative mood are linked to increased substance use. Early intervention should focus on emotional well-being and prevention, involving both families and schools.

Department of Art Education, University of Seville, 41003 Seville, Spain Department of Education, University of Cantabria, 39005 Santander, Spain

Low atmospheric temperatures during the Martian aphelion freeze water ice in the troposphere which is then cold trapped and unable to transit up into the mesosphere, according to a radiative transfer model and cloud microphysics simulations

Background/Objectives: Vitamin D (VD) deficiency has been associated with increased risk of gestational disorders affecting the endocrine system, immune system, and neurodevelopment in offspring. Recent studies have focused on the interaction between toxic elements and micronutrients during pregnancy. This review analyzes the potential relationships between VD levels and heavy metals in pregnant women and their offspring. Methods: A systematic review was conducted according to PRISMA 2020 guidelines, using databases such as PubMed, ScienceDirect, Cochrane Library, and Google Scholar. Boolean operators ‘AND’ and ‘OR’ were applied with terms like ‘pregnancy’, ‘vitamin D’, ‘heavy metals’, and ‘newborns’. Results: From 4688 articles, 14 studies were selected based on relevance and quality. These studies measured the levels of metals like lead (Pb), cadmium (Cd), mercury (Hg), and arsenic (As), in biological samples including maternal blood, umbilical cord blood, placenta tissue, and meconium during different stages of pregnancy, showing an inverse relationship between VD deficiency and heavy metal concentrations, which could be related to the incidence of preterm birth. Conclusions: The review highlights the importance of maintaining adequate VD levels during pregnancy, suggesting that sufficient VD may mitigate the adverse effects of heavy metal exposure, potentially reducing pregnancy-related complications.

Immunology Service, Virgen de la Arrixaca University Clinical Hospital (HCUVA), Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain

The occurrence of carbonyl compounds and volatile organic compounds (VOCs) in adult formulas is a critical issue in product safety and quality. This research manuscript reports the determination of targeted and untargeted carbonyl compounds and VOCs in adult formulas stored at different temperatures (room temperature, 4 °C, and 60 °C) over one month. Gas chromatography-mass spectrometry was utilized for the sample analysis. Ultrasound-assisted dispersive liquid–liquid microextraction at 60 °C for 20 min facilitated the extraction of six carbonyl compounds, while headspace solid-phase microextraction (HS-SPME) was employed for the determination of untargeted VOCs using a DVB/CAR/PDMS fiber, involving 15 min of equilibration and 45 min of extraction at 40 °C with magnetic stirring. Analytical features of the methods were assessed according to Food and Drug Administration guidelines, and good limits of detection and quantitation, linearity, accuracy, and precision were achieved. Notably, the highest levels of carbonyl compounds were found in high-protein formulas, with quantifiable levels of malondialdehyde, acrolein, and formaldehyde detected and quantified in 80% of samples. Additionally, significant levels of VOCs such as hexanal and 2-heptanone were found in samples stored at elevated temperatures. These findings suggest the importance of protein content and storage conditions in the levels of carbonyl compounds and VOCs found in adult formulas, with implications for consumer safety and quality control.

Abstract Objective To evaluate serum neuronal and inflammatory biomarkers in asphyxiated newborns treated with hypothermia alone or