María Teresa

Abstract Climate change induced shifts in treeline position, both towards higher altitudes and latitudes induce changes in soil organic matter.

Instituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico

Doctrinal texts on architectural heritage conservation emphasize the importance of fully understanding the structural and material characteristics and utilizing information systems. Photogrammetry allows for the generation of detailed, geo-referenced Digital Elevation Models of architectural elements at a low cost, while GIS software enables the addition of layers of material characteristic data to these models, creating different property maps that can be combined through map algebra. This paper presents the results of the mechanical characterization of materials and salt-related decay forms of the polygonal apse of the 13th-century monastery of Santa María de Bonaval (Guadalajara, Spain), which is primarily affected by salt crystallization. Rock strength is estimated using on-site nondestructive testing (ultrasound pulse velocity and Leeb hardness). They are mapped and combined through map algebra to derive a single mechanical soundness index (MSI) to determine whether the decay of the walls could be dependent on the orientation. The presented results show that salt decay in the building is anisotropic, with the south-facing side of the apse displaying an overall lower MSI than the others. The relative overheating of the south-facing side of the apse enhances the effect of salt crystallization, thereby promoting phase transitions between epsomite and hexahydrite.

Neutrophils, which constitute the most abundant leukocytes in human blood, emerge as crucial players in the induction of endothelial cell death and the modulation of endothelial cell responses under both physiological and pathological conditions. The hallmark of preeclampsia is endothelial dysfunction induced by systemic inflammation, in which neutrophils, particularly through the formation of neutrophil extracellular traps (NETs), play a pivotal role in the development and perpetuation of endothelial dysfunction and the hypertensive state. Considering the potential of numerous pharmaceutical agents to attenuate NET formation (NETosis) in preeclampsia, a comprehensive assessment of the extensively studied candidates becomes imperative. This review aims to identify mechanisms associated with the induction and negative regulation of NETs in the context of preeclampsia. We discuss potential drugs to modulate NETosis, such as NF-κβ inhibitors, vitamin D, and aspirin, and their association with mutagenicity and genotoxicity. Strong evidence supports the notion that molecules involved in the activation of NETs could serve as promising targets for the treatment of preeclampsia.

Department of Endocrinology and Nutrition, Hospital Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain

Basal Cell Carcinoma (BCC) is the most common type of cancer among the white population. Individuals with fair skin have an average lifetime risk of around 30% for developing BCC, and there is a noticeable upward trend in its incidence rate. The principal treatment objectives for BCC involve achieving the total excision of the tumor while maximizing the preservation of function and cosmesis. Surgery is considered the treatment of choice for BCC for two main reasons: it allows for the highest cure rates and facilitates histological control of resection margins. However, in the subgroup of patients with low-risk recurrence or medical contraindications for surgery, new non-surgical treatment alternatives can provide an excellent oncological and cosmetic outcome. An evident and justified instance of these local therapies occurred during the COVID-19 pandemic, a period when surgical interventions carried out in hospital settings were not a viable option.

Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain

Faculty of Health Sciences, University of Valladolid, 42004 Soria, Spain Clinical Research in Health Sciences Group, University of Valladolid, 42004 Soria, Spain

The intention of this Special Issue was to highlight the importance of the design, synthesis, and applications of macro-, meso-, and microporous materials [...]

This study assesses the adoption and operational effectiveness of Environmental Management Systems (EMSs) in Italian wineries, focusing on ISO 14001:2015. It evaluates commitment, planning, communication strategies, emergency preparedness, and employee training practices. Using a comprehensive survey-based methodology, the research elucidates the dynamics of EMS implementation across various scales of winery operations. The research reveals a strong commitment among wineries to environmental objectives such as waste reduction and efficient electricity and water use. However, significant deficiencies were identified in EMS policy implementation, emergency preparedness, and the uptake of ISO 14001:2015 certification, with larger wineries showing more robust engagement in environmental training than smaller ones. The study incorporates five key performance indicators (KPIs) and a predictive model using logistic regression and Random Forest to analyze the likelihood of ISO 14001 certification based on the analyzed variables. The model highlights established processes, environmental policies, and frequent reviews as significant predictors of certification. These findings contribute original value by identifying critical leverage points and barriers affecting EMS effectiveness within the wine sector. The research uncovers nuanced interactions between the scale of operations and management engagement influencing EMSs' success. It proposes novel, survey-based KPIs essential for assessing EMS performance in wineries, demonstrating their practical utility in pinpointing areas for improvement. The research limitations include potential biases from varying participation rates among surveyed wineries, affecting extrapolation to the broader Italian wine industry. Despite these limitations, the study provides substantive practical implications, suggesting that wineries can enhance both environmental sustainability and a competitive edge by addressing gaps in EMS implementation.