Wei Wang

Growing evidence suggests a link between inflammation and bipolar disorder (BD). Trials of repurposed immunomodulatory drugs in patients with BD have reported mixed results. Utilizing biomarkers to stratify treatment has been suggested as a way to personalize treatment with immunomodulatory drugs in neuropsychiatric disorders and improve outcomes. The neutrophil to lymphocyte ratio (NLR) is one such candidate biomarker but is yet to be extensively assessed in bipolar depression and in populations in low and middle-income settings.

Abstract The grain size in cereals is one of the main component traits contributing to yield.

Epsilon-near-zero (ENZ) materials offer promising candidates for the study of strong light-matter interactions due to their exotic optical properties. Quasibound states in the continuum (QBICs) supported by all-dielectric metasurfaces possess the characteristics of high quality factors with flexible tunability, allowing for significant field enhancement and more degrees of freedom for manipulating light-matter interaction at the nanoscale. Here, we propose a two-dimensional all-dielectric metasurface combined with a thin polar dielectric film, which supports the ENZ mode and the inherent transverse optical (TO) phonon mode. We demonstrate a strong QBIC-ENZ coupling with giant and highly tunable coupling strengths. The proposed metasurface can not only support QBIC modes, but can also excite the ENZ mode in polar dielectric film. With the help of the strong field localization and flexible modulation properties of QBIC, we further realize a selective QBIC-ENZ-TO three-mode strong coupling in the hybrid system, demonstrating a large Rabi splitting over 22.1 meV (178 cm− 1) at room temperature, which is four times higher than that of the QBIC-ENZ two-mode coupling. We also demonstrate that the three-mode coupling strength can be easily tuned by varying the thickness of the ENZ thin film, which provides an effective approach for the manipulation of the strong light-matter interaction. The proposed all-dielectric platform exhibits strong coupling strength and flexible design tunability, which is expected to provide a different route for the design of ultracompact optical devices at mid-infrared frequencies.

Abstract Background and Purpose Due to the complexity of traditional Chinese medicine based on complex mixtures of natural products

Ischemic stroke presents a global health challenge, necessitating an in-depth comprehension of its pathophysiology and therapeutic strategies. While reperfusion therapy salvages brain tissue, it also triggers detrimental cerebral ischemia-reperfusion injury (CIRI). In our investigation, we observed the activation of nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy in an oxygen-glucose deprivation/reoxygenation (OGD/R) model using HT22 cells (

The rising prevalence of short-form video addiction among adolescents has raised researchers’ concerns. However, the antecedents of adolescents’ short-form video addiction, particularly in relation to the attachments to fathers and mothers, remain inadequately explored. To bridge the gap, this study aimed to explore the relationship between adolescents’ attachment anxiety to fathers/mothers and their short-form video addiction, as well as the mediating role of fear of missing out (FoMO) and the moderating role of gender in these associations. The sample was 4,213 Chinese adolescents (2,001 girls;

Liu-Liu Shen Xiangzun Dong Wei Wang Hui Yu Peiran Wu Jiansong Wang

This book constitutes the refereed post-conference proceedings of the 29th International Conference on Selected Areas in Cryptography, SAC 2022, held in Windsor, Canada, during August 24–26, 2022.

This paper empirically examines the heterogeneous impacts of sudden stops in international capital flows on economic growth. We identified 24 sudden stop episodes since 1990 and employed a counterfactual method with cross-economy panel data to evaluate the impact of each episode on economic growth. The results indicate that 14 sudden stop episodes triggered significant economic decline, with varying magnitudes; 9 episodes were accompanied by insignificant economic downturn, and 1 episode was followed by economic growth. We further utilize the treatment effect derived from the counterfactual analysis to investigate the causes of these heterogeneous impacts of sudden stops on economic growth. Results obtained from the panel data model suggest that external debt, financial development, and real investment return are the main driving forces contributing to the observed heterogeneity.

Cells that collide with each other repolarize away from contact, in a process called contact inhibition of locomotion (CIL), which is necessary for correct development of the embryo. CIL can occur even when cells make a micron-scale contact with a neighbor—much smaller than their size. How precisely can a cell sense cell-cell contact and repolarize in the correct direction? What factors control whether a cell recognizes it has contacted a neighbor? We propose a theoretical model for the limits of CIL where cells recognize the presence of another cell by binding the protein ephrin with the Eph receptor. This recognition is made difficult by the presence of interfering ligands that bind nonspecifically. Both theoretical predictions and simulation results show that it becomes more difficult to sense cell-cell contact when it is difficult to distinguish ephrin from the interfering ligands, or when there are more interfering ligands, or when the contact width decreases. However, the error of estimating contact position remains almost constant when the contact width changes. This happens because the cell gains spatial information largely from the boundaries of cell-cell contact. We study using statistical decision theory the likelihood of a false-positive CIL event in the absence of cell-cell contact, and the likelihood of a false negative where CIL does not occur when another cell is present. Our results suggest that the cell is more likely to make incorrect decisions when the contact width is very small or so large that it nears the cell's perimeter. However, in general, we find that cells have the ability to make reasonably reliable CIL decisions even for very narrow (micron-scale) contacts, even if the concentration of interfering ligands is ten times that of the correct ligands.