Maria João

Considering the increase in the production and use of nanomaterials (NM) in food/feed and food contact materials, novel strategies for efficient and sustainable hazard characterization, especially in the early stages of NM development, have been proposed. Some of these strategies encompass the utilization of in vitro simulated digestion prior to cytotoxic and genotoxic assessment. This entails exposing NM to fluids that replicate the three successive phases of digestion: oral, gastric, and intestinal. Subsequently, the resulting digestion products are added to models of intestinal cells to conduct toxicological assays, analyzing multiple endpoints. Nonetheless, exposure of intestinal cells to the digested products may induce cytotoxicity effects, thereby posing a challenge to this strategy. The aim of this work was to describe the challenges encountered with the in vitro digestion INFOGEST 2.0 protocol when using the digestion product in toxicological studies of NM, and the adjustments implemented to enable its use in subsequent in vitro biological assays with intestinal cell models. The adaptation of the digestion fluids, in particular the reduction of the final bile concentration, resulted in a reduced toxic impact of digestion products.

UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal

(1) Background: The transition to twin parenthood is a demanding challenge with a higher risk of maternal and fetal complications during pregnancy and a postpartum period that involves caring for more than one newborn at the same time with similar and simultaneous needs. (2) Aim: To find out about parents' needs when experiencing the transition to twin parenthood and to describe the intervention of their specialized nursing support network. (3) Methodology: A descriptive exploratory study, based on a proper non-probabilistic sample of 15 nurses and 55 couples who are parents of twins, using two online questionnaires publicized on social networks. (4) Results: The couple's needs were identified through knowledge of their experiences and difficulties during pregnancy and after the twin birth. Couples' and nurses' perceptions differed on the identified needs. The specialized nursing support network focuses its intervention on providing informative guidance on twin pregnancy and postpartum period, health education, group sharing experiences, home visits, planning, and including a family support network in the management of twin care and the creation of a daily routine. (5) Conclusions: There is a need to implement a program focused on the needs of parents of twins, promoting realistic expectations for the birth and parenting of twins, preparing parents, improving their well-being, and creating a specialized nursing support network available to this population.

LAQV-REQUIMTE, Department of Conservation and Restoration, NOVA School of Sciences and Technology, NOVA University of Lisbon, Campus da Caparica, 2829-516 Caparica, Portugal

Typesetting math: 100% CESAM and Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal

Centre of Marine Sciences (CCMAR/CIMAR LA), Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal

Department of Epidemiology and Biostatistics, College of Public Health, Temple University, Philadelphia, PA 19122, USA

The rapid development of 5G networks and the anticipation of 6G technologies have ushered in an era of highly customizable network environments facilitated by the innovative concept of network slicing. This technology allows the creation of multiple virtual networks on the same physical infrastructure, each optimized for specific service requirements. Despite its numerous benefits, network slicing introduces significant security vulnerabilities that must be addressed to prevent exploitation by increasingly sophisticated cyber threats. This review explores the application of cutting-edge technologies—Artificial Intelligence (AI), specifically Machine Learning (ML), Software-Defined Networking (SDN), and Network Functions Virtualization (NFV)—in crafting advanced security solutions tailored for network slicing. AI's predictive threat detection and automated response capabilities are analysed, highlighting its role in maintaining service integrity and resilience. Meanwhile, SDN and NFV are scrutinized for their ability to enforce flexible security policies and manage network functionalities dynamically, thereby enhancing the adaptability of security measures to meet evolving network demands. Thoroughly examining the current literature and industry practices, this paper identifies critical research gaps in security frameworks and proposes innovative solutions. We advocate for a holistic security strategy integrating ML, SDN, and NFV to enhance data confidentiality, integrity, and availability across network slices. The paper concludes with future research directions to develop robust, scalable, and efficient security frameworks capable of supporting the safe deployment of network slicing in next-generation networks.

This systematic literature review evaluates the benefits of judo practice designed for individuals with neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), Intellectual Developmental Disorders (IDDs), and attention-deficit/hyperactivity disorder (ADHD). This review adheres to the PRISMA 2020 guidelines, focusing on the physical, social, emotional, and cognitive benefits of judo. A comprehensive search across databases, such as PubMed, Google Scholar, ResearchGate, B-On, and Scopus, was conducted, and relevant studies were selected based on explicit inclusion and exclusion criteria. Sixteen intervention studies were included, which contributed to a detailed understanding of the impact of judo. The results indicated significant benefits in terms of physical activity, social interactions, emotional well-being, and cognitive functions among participants. A synthesis of results is presented, showing the overall positive effect of judo practice. This review highlights the potential of judo as supportive therapy for individuals with NDDs, advocating its inclusion in therapeutic and educational settings. Limitations due to study heterogeneity and the need for more randomized controlled trials are also discussed.

Climate change is one of the most important challenges for mankind in the far and near future. In this regard, sustainable production of woody crops on marginal land with low water availability is a major challenge to tackle. This dataset is part of an experiment, in which we exposed three genetically differentiated genotypes of Populus nigra originating from contrasting natural habitats to gradually increasing moderate drought. RNA sequencing was performed on fine roots, developing xylem and leaves of those three genotypes under control and moderate drought conditions in order to get a comprehensive dataset on the transcriptional changes at the whole plant level under water limiting conditions. This dataset has already provided insight in the transcriptional control of saccharification potential of the three Populus genotypes under drought conditions and we suggest that our data will be valuable for further in-depth analysis regarding candidate gene identification or, on a bigger scale, for meta-transcriptome analysis.