Maria João

This study aligns with the Rural Pact’s Long-Term Vision for European Rural Areas by encouraging multi-level collaboration and stakeholder engagement to address rural needs. Using a Human Ecology perspective, it challenges rural stereotypes, promotes spatial justice and aims to reduce rural–urban disparities by fostering social innovation and youth entrepreneurship in rural areas. A thematic analysis of semi-structured interviews identified six key dimensions and their sub-dimensions within a transformative social–ecological model. The notable sub-dimensions include “Local Experimentation and Creativity” in Civil Society, “Higher Education Institutions and Lifelong Learning” in Knowledge and Skills, “Formal Institutional Monitoring at the National Level” in a Political and Institutional Context, and “Profiles—Young Age and Gender” in Entrepreneurship.

UCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal

Hypertrophic cardiomyopathy (HCM) is a heterogeneous cardiac disease and one of its major challenges is the limited accuracy in stratifying the risk of sudden cardiac death (SCD). Positron emission tomography (PET), through the evaluation of myocardial blood flow (MBF) and metabolism using fluorodeoxyglucose (FDG) uptake, can reveal microvascular dysfunction, ischemia, and increased metabolic demands in the hypertrophied myocardium. These abnormalities are linked to several factors influencing disease progression, including arrhythmia development, ventricular dilation, and myocardial fibrosis. Fibroblast activation can also be evaluated using PET imaging, providing further insights into early-stage myocardial fibrosis. Conflicting findings underscore the need for further research into PET's role in risk stratification for HCM. If PET can establish a connection between parameters such as abnormal MBF or increased FDG uptake and SCD risk, it could enhance predictive accuracy. Additionally, PET holds significant potential for monitoring therapeutic outcomes. The aim of this review is to provide a comprehensive overview of the most significant data on disease progression, risk stratification, and prognosis in patients with HCM using cardiac PET-CT imaging.

This study developed and refined the Judo Teachers’ Attitudes Towards Including Participants with Intellectual Developmental Disorders (J-TAID) survey, addressing the need to assess attitudes, subjective norms, perceived behavioral control, and intention regarding inclusion, and grounded in the Theory of Planned Behavior. The survey, translated into English, Portuguese, French, and Slovenian, was administered to 163 participants in order to assess its reliability and validity using Cronbach’s alpha, Principal Component Analysis (PCA), Confirmatory Factor Analysis (CFA), and Exploratory Factor Analysis (EFA). Internal consistency regarding attitudes, subjective norms, and perceived behavioral Constructs ranged from 0,79 to 0.80, with test–retest reliability improving, demonstrating moderate to strong temporal stability (α = 0.679–0.813). The PCA and CFA identified a robust three-factor structure explaining 74% of the variance, with good model fit (RMSEA = 0.048, CFI = 0.978). Pearson correlations supported the TPB constructs. The refined J-TAID demonstrates validity and reliability for its intended purpose, although the results are still preliminary, and the limitations that were observed suggest a need for further validation.

Background: Capsule endoscopy (CE) improved the digestive tract assessment; yet, its reading burden is substantial. Deep-learning (DL) algorithms were developed for the detection of enteric and gastric lesions. Nonetheless, their application in the esophagus lacks evidence. The study aim was to develop a DL model for esophageal pleomorphic lesion (PL) detection. Methods: A bicentric retrospective study was conducted using 598 CE exams. Three different CE devices provided 7982 esophageal frames, including 2942 PL lesions. The data were divided into the training/validation and test groups, in a patient-split design. Three runs were conducted, each with unique patient sets. The sensitivity, specificity, accuracy, positive and negative predictive value (PPV and NPV), area under the conventional receiver operating characteristic curve (AUC-ROC), and precision–recall curve (AUC-PR) were calculated per run. The model's diagnostic performance was assessed using the median and range values. Results: The median sensitivity, specificity, PPV, and NPV were 75.8% (63.6–82.1%), 95.8% (93.7–97.9%), 71.9% (50.0–90.1%), and 96.4% (94.2–97.6%), respectively. The median accuracy was 93.5% (91.8–93.8%). The median AUC-ROC and AUC-PR were 0.82 and 0.93. Conclusions: This study focused on the automatic detection of pleomorphic esophageal lesions, potentially enhancing the diagnostic yield of this type of lesion, compared to conventional methods. Specific esophageal DL algorithms may provide a significant contribution and bridge the gap for the implementation of minimally invasive CE-enhanced panendoscopy.

Abstract High-resolution anorectal manometry (HR-ARM) is the gold standard for anorectal functional disorders' evaluation, despite being limited by its accessibility and complex data analysis.

Faculty of Health Sciences, University Fernando Pessoa, Rua Carlos da Maia, 296, 4200-150 Porto, Portugal

The prevalence of metabolic syndrome has been exponentially increasing in recent decades. Thus, there is an increasing need for affordable and natural interventions for this disorder. We explored the effect of chrysin, a dietary polyphenol, on hepatic lipid and glycogen accumulation, metabolic dysfunction-associated fatty liver disease (MAFLD) activity score and oxidative stress and on hepatic and adipose tissue metabolism in rats presenting metabolic syndrome-associated conditions. Rats fed a chow diet were separated into four groups: Control (tap water), Fructose (tap water with 10% fructose), Chrysin (tap water+ chrysin (100 mg/kg body weight/d)), and Fructose + Chrysin (tap water with 10% fructose + chrysin (100 mg/kg body weight/d, daily)) (for 18 weeks). When associated with the chow diet, chrysin reduced hepatic lipid and glycogen storage, increased the hepatic antioxidant potential of glutathione and reduced de novo lipogenesis in the adipose tissue. When associated with the high fructose-diet, chrysin attenuated the increase in lipid and glycogen hepatic storage, improved the MAFLD activity score, decreased hepatic lipid peroxidation, increased the antioxidant potential of glutathione, and improved lipid and glucose metabolic markers in the liver and adipose tissue. In conclusion, our results suggest that chrysin is a beneficial addition to a daily diet for improvement of hepatic metabolic health, particularly for individuals suffering from metabolic syndrome.

Chromosomal aberrations are rare but known causes of movement disorders, presenting with broad phenotypes in which dystonia may be predominant. During the investigation of such cases, chromosomal studies are not often considered as a first approach. In this article, the authors describe a family affected by a generalized form of dystonia, evolving from a focal phenotype, for which a new X chromosome large duplication was found to be the likely causative, therefore highlighting the role of such studies when facing complex movement disorders.

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